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Evidence memo

Ibogaine

Also tracked as: Iboga alkaloid

An addiction-treatment research compound with high public interest and unusually important cardiac safety concerns.

Safety/regulatory watch Investigational Safety watch

Evidence status

Safety/regulatory watch. Evidence level: Safety/regulatory watch.

Claim being evaluated

Whether potential addiction-treatment signals can be studied in a standardized way that addresses cardiac and neurologic safety risks.

Why people care

Ibogaine is discussed for opioid and substance-use disorders, often by people seeking options after failed standard approaches.

Signal so far

There are observational and translational signals, but safety literature includes serious cardiac-risk concerns.

Biggest unknown

Whether a regulated clinical pathway can separate any therapeutic signal from unacceptable acute risk.

Safety/regulatory boundary

This is a safety/regulatory watch item. The Watchlist does not provide clinic, sourcing, or use guidance.

Watch next

Controlled trials, cardiac monitoring standards, analog development, and regulatory decisions.

Evidence interpretation

The safety boundary is not a footnote; it is the center of the evidence map.

References